Mitochondrial Matrix Ca 2+ Accumulation Regulates Cytosolic NAD + /NADH Metabolism, Protein Acetylation, and Sirtuin Expression
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چکیده
منابع مشابه
Mitochondrial matrix Ca²⁺ accumulation regulates cytosolic NAD⁺/NADH metabolism, protein acetylation, and sirtuin expression.
Mitochondrial calcium uptake stimulates bioenergetics and drives energy production in metabolic tissue. It is unknown how a calcium-mediated acceleration in matrix bioenergetics would influence cellular metabolism in glycolytic cells that do not require mitochondria for ATP production. Using primary human endothelial cells (ECs), we discovered that repetitive cytosolic calcium signals (oscillat...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2014
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00068-14